|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
We deleted one copy of the MIIP gene in HCT116 CRC cells using zinc finger nuclease technology and demonstrated that MIIP haploinsufficiency resulted in increased colony formation and cell migration and invasion, which was consistent with the results from siRNA-mediated MIIP knockdown in two CRC cell lines (p < 0.05 for all).
|
27741356 |
2017 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Twenty-six percent (37/142) of tumors were shown to have LOH at the MIIP locus by MS and SNP markers.
|
25873164 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Transwell and wound-healing assays were used to detect cell invasion and migration after MIIP overexpression.
|
31078343 |
2019 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
To test this hypothesis, we sequenced the IIp45 gene in 59 diffuse glioma samples of different grades and histologic subtypes and identified a possible point mutation or a rare polymorphism in only one sample (1.7%), suggesting that IIp45 is not a classic tumor suppressor gene such as p53.
|
15867349 |
2005 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
To test this hypothesis, we sequenced the IIp45 gene in 59 diffuse glioma samples of different grades and histologic subtypes and identified a possible point mutation or a rare polymorphism in only one sample (1.7%), suggesting that IIp45 is not a classic tumor suppressor gene such as p53.
|
15867349 |
2005 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings uncover an unidentified mechanism underlying the precise regulation of NF-κB by EGF, and highlight the critical role of nuclear MIIP in tumor metastasis.In colorectal cancer, EGFR signalling is implicated in metastasis.
|
29038521 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC.
|
27741356 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC.
|
27741356 |
2017 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The gene encoding migration and invasion inhibitory protein (MIIP), located on 1p36.22, is a potential tumour suppressor gene in glioma.
|
27741356 |
2017 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The MIIP gene was transfected into NPC 5-8F and CNE2 cells.
|
29805670 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The IIp45 protein was not expressed in some GBMs.
|
14617774 |
2003 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have characterized the migration and invasion inhibitory protein (MIIP) as a novel putative tumor-suppressor gene that regulates cell migration and invasion as well as the mitotic checkpoint.
|
25873164 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.
|
29038521 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our study further emphasized the tumor suppressive role of MIIP and illustrated a novel mechanism.
|
31092266 |
2019 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that the MIIP protein was reduced or undetectable in some tissue samples obtained from patients with glioblastoma.
|
20418911 |
2010 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that the MIIP protein was reduced or undetectable in some tissue samples obtained from patients with glioblastoma.
|
20418911 |
2010 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that the MIIP protein was reduced or undetectable in some tissue samples obtained from patients with glioblastoma.
|
20418911 |
2010 |